Summary

The Partridge lab works on the biology of ageing. Their research is directed to understanding both how the rate of ageing evolves in nature and the mechanisms by which healthy lifespan can be extended in laboratory model organisms.

Related entries

Publication Citations

• Azevedo, Ricardo B. R., French, Vernon & Partridge, Linda, 'Thermal evolution of egg size in Drosophila melanogaster', Evolution, vol. 50, no. 6, 1996, pp. 2338-2345. http://www.jstor.org/stable/2410702. Details
• Azevedo, Ricardo B. R., James, Avis C., McCabe, Jennie & Partridge, Linda, 'Latitudinal variation of wing: thorax size ratio and wing-aspect ratio in Drosophila melanogaster', Evolution, vol. 52, no. 5, 1998, pp. 1353-1362. http://www.jstor.org/stable/2411305. Details
• Gockel, Julia, Kennington, W. Jason, Hoffmann, Ary, Goldstein, David B., and Partridge, Linda, 'Nonclinality of Molecular Variation Implicates Selection in Maintaining a Morphological Cline of Drosophila melanogaster', Genetics, vol. 158, no. 1, 2001, pp. 319-323. http://www.genetics.org/content/158/1/319.full. Details
• Hoffmann, A. A., Scott, M., Partridge, L. and Hallas, R., 'Overwintering in Drosophila melanogaster: outdoor field cage experiments on clinal and laboratory selected populations help to elucidate traits under selection', Journal of Evolutionary Biology, vol. 16, 2003, pp. 614-623. http://dx.doi.org/10.1046/j.1420-9101.2003.00561.x. Details
• James, Avis C. & Partridge, Linda, 'Thermal evolution of rate of larval development in Drosophila melanogaster in laboratory and field populations', Journal of Evolutionary Biology, vol. 8, no. 3, 1995, pp. 315-330. http://dx.doi.org/10.1046/j.1420-9101.1995.8030315.x. Details
• James, Avis C., Azevedo, Ricardo B. R. & Partridge, Linda, 'Cellular Basis and Developmental Timing in a Size Cline of Drosophila melanogaster', Genetics, vol. 140, 1995, pp. 659-666. http://www.genetics.org/content/140/2/659.full.pdf. Details
• James, Avis C., Azevedo, Ricardo B. R. and Partridge, Linda, 'Genetic and Environmental Responses to Temperature of Drosophila melanogaster From a Latitudinal Cline', Genetics, vol. 146, no. 3, 1997, pp. 881-890. http://www.genetics.org/content/146/3/881.full.pdf. Details
• Kennington, W.J., Partridge, L., and Hoffmann, A. A., 'Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation', Genetics, vol. 172, 2006, pp. 1655-1663. http://dx.doi.org/10.1534/genetics.105.053173. Details
• Lee, S.F., Chen Y., Reuter, C., Vinti, G., Rane, R.V., Rako, L., Partridge, L. and Hoffmann, A.A., 'Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster', Molecular Ecology, vol. 22, no. 10, 2013, pp. 2716-2725. http://dx.doi.org/10.1111/mec.12301. Details

See also

• Chen, Y., Lee, S. F., Blanc, E., Reuter, C., Wertheim, B., Martinez-Diaz, P., Hoffmann, A. A., and Partridge, L., 'Genome-wide transcription analysis of clinal genetic variation in Drosophila', PLoS One, vol. 7, no. 4, 2012, pp. 1-8. http://dx.doi.org/10.1371/journal.pone.0034620. Details
• Kennington, W.J., Hoffmann, A. A., and Partridge, L., 'Mapping regions within cosmopolitan inversion In(3R)Payne associated with natural variation in body size in Drosophila melanogaster', Genetics, vol. 177, 2007, pp. 549-556. http://dx.doi.org/10.1534/genetics.107.074336. Details
• Lee, Siu F., Chen, Ying, Varan, Aiden K., Wee, Choon W., Rako, Lea, Axford, Jason K., Good, Robert T., Blacket, Mark J., Reuter, Caroline, Partridge, Linda, and Hoffmann, Ary A., 'Molecular basis of adaptive shift in body size in Drosophila melanogaster : Functional and sequence analyses of the Dca gene', Molecular Biology and Evolution, vol. 28, no. 8, 2011, pp. 2392-2402. http://dx.doi.org/10.1093/molbev/msr064. Details