Grant Clinal variation in Drosophila; a signature of climatic adaptation and a resource for adaptive gene discovery

Australian Research Council Discovery Project

Alternative Names
  • (ARC ID)
Bio21 Molecular Science & Biotechnology Institute 30 Flemington Road, The University of Melbourne, Parkville VIC 3010, Australia


The project titled 'Clinal variation in Drosophila; a signature of climatic adaptation and a resource for adaptive gene discovery' was a Discovery Project completed by the Hoffmann lab and funded by the Australian Research Council. The project commenced in 2012 with a budget of $AUD 600000. Evolutionary changes can occur rapidly within populations and genetic changes in traits along gradients represent an expression of these rapid changes. The project aimed to study clinal variation on the east coast of Australia, as it represents an outstanding natural laboratory to understand these changes using drosophila flies as model systems.

Publication Citations

  • Lee, S.F., Chen Y., Reuter, C., Vinti, G., Rane, R.V., Rako, L., Partridge, L. and Hoffmann, A.A., 'Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster', Molecular Ecology, vol. 22, no. 10, 2013, pp. 2716-2725. Details
  • Sgrò, Carla M., van Heerwaarden, Belinda, Kellermann, Vanessa, Wee, Choon W., Hoffmann, Ary A., and Lee, Siu F., 'Complexity of the genetic basis of ageing in nature revealed by a clinal study of lifespan and methuselah, a gene for ageing, in Drosophila from eastern Australia', Molecular Ecology, vol. 22, no. 13, 2013, pp. 3539-3551. Details

See also

  • Overgaard, J., Kearney, M. R. and Hoffmann, A. A., 'Sensitivity to thermal extremes in Australian Drosophila implies similar impacts of climate change on the distribution of widespread and tropical species', Global Change Biology, vol. 20, no. 6, 2014, pp. 1738-1750. Details
  • Schiffer, Michele, Hangartner, Sandra, and Hoffmann, Ary A., 'Assessing the relative importance of environmental effects, carry-over effects and species differences in thermal stress resistance: a comparison of Drosophilids across field and laboratory generations', Journal of Experimental Biology, vol. 216, no. 20, 2013, pp. 3790-3798.​jeb.085126. Details